2. Signaling Pathways
  3. GPCR/G Protein
    Neuronal Signaling
  4. Neuropeptide Y Receptor

Neuropeptide Y Receptor

NPY receptor

Neuropeptide Y Receptor

Related Products

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Neuropeptide Y receptors belong G protein-coupled receptor superfamily and comprise various subtypes. There are currently five cloned NPY receptor subtypes in mammals, termed Y1, Y2, Y4, Y5, and Y6. Neuropeptide Y receptors mediate a variety of physiological responses including feeding and vasoconstriction.

Subtypes Y1, Y2, Y4 and Y5 are expressed in humans. They are present mainly in the central and peripheral nervous systems as well as other tissues, such as the cardiovascular system. Their physiologic ligands are the neurotransmitter Neuropeptide Y and the 2 hormones peptide YY (PYY) and pancreatic polypeptide (PP).

Neuropeptide Y and its receptors regulate important biological and pathophysiological functions, such as blood pressure, neuroendocrine secretions, seizures, neuronal excitability and neuroplasticity.

Neuropeptide Y Receptor Isoform Specific Products:

Neuropeptide Y Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-118198
    NPY Y2 antagonist 1
    		Antagonist
    NPY Y2 antagonist 1 (compound 36) is a pyridine-type, selective neuropeptide Y receptor (NPY) Y2 antagonist.
    NPY Y2 antagonist 1
  • HY-RS09515
    Npy2r Mouse Pre-designed siRNA Set A
    		Inhibitor

    Npy2r Mouse Pre-designed siRNA Set A contains three designed siRNAs for Npy2r gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
    Npy2r Mouse Pre-designed siRNA Set A
  • HY-107727
    BMS-193885 L-Lactic acid
    		Antagonist
    BMS-193885 (L-Lactic acid) is a potent, selective, and brain-penetrant neuropeptide Y1 receptor antagonist. BMS-193885 has a Ki value of 3.3 nM for the neuropeptide Y1 receptor, competitively acts on the neuropeptide Y binding site, and can reduce food intake and body weight through central Y1 inhibition.
    BMS-193885 L-Lactic acid
  • HY-P1322A
    [D-Trp34]-Neuropeptide Y TFA
    		Agonist
    [D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats.
    [D-Trp34]-Neuropeptide Y TFA
  • HY-107735R
    CYM 9484 (Standard)
    		Antagonist
    CYM 9484 (Standard) is the analytical standard of CYM 9484 (HY-107735). This product is intended for research and analytical applications. CYM 9484 is a selective and highly potent neuropeptide Y (NPY) Y2 receptor antagonist with an IC50 value of 19 nM.
    CYM 9484 (Standard)
  • HY-122021
    J-115814
    		Antagonist
    J-115814 is a potent and selective neuropeptide Y1 antagonist with Ki values of 1.4, 1.8, 1.9, >10000, 620, 6000, >10000 nM for hY1, rY1, mY1, hY2, hY4, hY5, mY6, respectively. J-115814 inhibits feeding behaviors.
    J-115814
  • HY-P1400
    Neuropeptide Y (scrambled)
    		Control
    Neuropeptide Y (scrambled) is a scrambled peptide that serves as a negative control for Neuropeptide Y.
    Neuropeptide Y (scrambled)
  • HY-103536AR
    Galnon TFA (Standard)
    		Agonist
    Galnon TFA (Standard) is the analytical standard of Galnon TFA (HY-103536A). This product is intended for research and analytical applications. Galnon TFA is a selective and non-peptide agonist of galanin GAL1 and GAL2 receptor, with Kis of 11.7 and 34.1 μM respectively. Galnon TFA exhibits anticonvulsant and anxiolytic effects.
    Galnon TFA (Standard)
  • HY-107734R
    L 152804 (Standard)
    		Antagonist
    L 152804 (Standard) is the analytical standard of L 152804 (HY-107734). This product is intended for research and analytical applications. L 152804 is an orally active and selective neuropeptide Y Y5 receptor (NPY5-R) antagonist, with a Ki of 26 nM for hY5. L 152804 causes weight loss in diet-induced obese mice by modulating food intake and energy expenditure.
    L 152804 (Standard)
  • HY-107728R
    S 25585 (Standard)
    		Antagonist
    S 25585 (Standard) is the analytical standard of S 25585 (HY-107728). This product is intended for research and analytical applications. S 25585 is a potent and selective neuropeptide Y (NPY) Y5 receptor antagonist. S 25585 reduces food intake but not through blockade of the NPY Y5 receptor.
    S 25585 (Standard)
  • HY-107730R
    NPY5RA-972 (Standard)
    		Antagonist
    NPY5RA-972 (Standard) is the analytical standard of NPY5RA-972 (HY-107730). This product is intended for research and analytical applications. NPY5RA-972 is an orally active, central nervous system (CNS) penetrating, potent and selective NPY Y5 receptor antagonist that prevents feeding driven by activation of this receptor.
    NPY5RA-972 (Standard)
  • HY-100717R
    HT-2157 (Standard)
    		Antagonist
    HT-2157 (Standard) is the analytical standard of HT-2157 (HY-100717). This product is intended for research and analytical applications. HT-2157 (SNAP 37889) is a selective, high-affinity, competitive antagonists of galanin-3 receptor (Gal3).
    HT-2157 (Standard)
  • HY-101986R
    BIIE-0246 (Standard)
    		Antagonist
    BIIE-0246 (Standard) is the analytical standard of BIIE-0246 (HY-101986). This product is intended for research and analytical applications. BIIE-0246 (AR-H 053591) is a potent and selective NPY2R (neuropeptide Y receptor 2) antagonist with an IC50 value of 15 nM for rat [125I]PYY3-36. BIIE-0246 decreases the expression of p-AKT S473, P-p44/42 MAPK under the NPY-stimulated. BIIE-0246 reduces albuminuria in ADR nephropathy.
    BIIE-0246 (Standard)
  • HY-107726R
    BIBP3226 TFA (Standard)
    		Antagonist
    BIBP3226 TFA (Standard) is the analytical standard of BIBP3226 (TFA) (HY-107726). This product is intended for research and analytical applications. BIBP3226 TFA is a potent and selective neuropeptide Y Y1 (NPY Y1) and neuropeptide FF (NPFF) receptor antagonist, with Kis of 1.1, 79, and 108 nM for rNPY Y1, hNPFF2, and rNPFF, respectively. BIBP3226 TFA displays anxiogenic-like effect.
    BIBP3226 TFA (Standard)
  • HY-107382R
    RF9 (Standard)
    		Antagonist
    RF9 (Standard) is the analytical standard of RF9 (HY-107382). This product is intended for research and analytical applications. RF9 is a potent and selective Neuropeptide FF receptor antagonist, with Ki values of 58 and 75 nM for hNPFF1R and hNPFF2R, respectively.
    RF9 (Standard)
  • HY-107725R
    BIBO3304 (Standard)
    		Antagonist
    BIBO3304 (Standard) is the analytical standard of BIBO3304 (HY-107725). This product is intended for research and analytical applications. BIBO3304, a chemical probe, is a potent, orally active, and selective neuropeptide Y (NPY) Y1 receptor antagonist, with subnanomolar affinity for both the human and the rat Y1 receptor (IC50=0.38 and 0.72 nM, respectively).
    BIBO3304 (Standard)
  • HY-U00335
    FR252384
    		Antagonist
    FR252384 is a neuropeptide Y-Y5 receptor antagonist, with an IC50 of 2.3 nM.
    FR252384
Cat. No. Product Name / Synonyms Application Reactivity
Neuropeptide Y Receptor Isoform Comparison

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